Pooled genome wide association detects association upstream of FCRL3 with Graves' disease

Abstract

Background: Graves' disease is an autoimmune thyroid disease of complex inheritance. Multiple genetic susceptibility loci are thought to be involved in Graves' disease and it is therefore likely that these can be identified by genome wide association studies. This study aimed to determine if a genome wide association study, using a pooling methodology, could detect genomic loci associated with Graves' disease.

Authors Khong, Jwu Jin; Burdon, Kathryn P.; Lu, Yi; Laurie, Kate; Leonardos, Lefta; Baird, Paul N.; Sahebjada, Srujana; Walsh, John P.; Gajdatsy, Adam; Ebeling, Peter R.; Hamblin, Peter Shane; Wong, Rosemary; Forehan, Simon P.; Fourlanos, Spiros; Roberts, Anthony P.; Doogue, Matthew; Selva, Dinesh; Montgomery, Grant W.; Macgregor, Stuart; Craig, Jamie E.
Journal BMC GENOMICS
Pages
Volume 17
Date 1/11/2016
Grant ID
Funding Body Ophthalmic Research Institute of Australia
URL http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1186/s12864-016-3276-z