2, p<0.001) and had lower baseline TLR7 gene expression (odds ratio (OR)=0.12, p=0.02) than controls. Associations between many variables and cold frequency differed between women and men. In women, high blood neutrophil counts (beta=0.096, p=0.002), and younger age (beta= -0.017, p<0.001), but not exposure to children, were independently associated with more frequent colds. In men, low TLR7 expression (beta= -0.96, p=0.041) and high CLEC4C gene expression (a marker of pDC; beta=0.88, p=0.008) were independently associated with more frequent colds. Poor asthma symptom control was independently associated with reduced TLR8 gene expression (beta= -1.4, p=0.036) and high BMI (beta=0.041, p=0.004).Asthma, age and markers of inflammation and antiviral immunity in peripheral blood are associated with frequent colds. Interestingly, the variables associated with cold frequency differed between women and men.
| Authors | Murray, Liisa M; Yerkovich, Stephanie T; Ferreira, Manuel A; Upham, John W |
|---|---|
| Journal | European Respiratory Journal |
| Pages | |
| Volume | 56 |
| Date | 1/06/2020 |
| Grant ID | APP1128010 |
| Funding Body | NHMRC (Australia) |
| URL | http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1183/13993003.02453-2019 |