Safety, pharmacokinetics, and antimalarial activity of the novel triaminopyrimidine ZY-19489: a first-in-human, randomised, placebo-controlled, double-blind, single ascending dose study, pilot food-effect study, and volunteer infection study.
Barber, Bridget E; Fernandez, Melissa; Patel, Hardik Babubhai; Barcelo, Catalina; Woolley, Stephen D; Patel, Harilal; Llewellyn, Stacey; Abd-Rahman, Azrin N; Sharma, Sunil; Jain, Mukul; Ghoghari, Ashok; Di Resta, Ilaria; Fuchs, Aline; Deni, Ioanna; Yeo, Tomas; Mok, Sachel; Fidock, David A; Chalon, Stephan; Möhrle, Jörg J; Parmar, Deven; McCarthy, James S; Kansagra, Kevinkumar
The Lancet. Infectious diseases - 1/01/2022
ALS monocyte-derived microglia-like cells reveal cytoplasmic TDP-43 accumulation, DNA damage, and cell-specific impairment of phagocytosis associated with disease progression.
Quek, Hazel; Cuní-López, Carla; Stewart, Romal; Colletti, Tiziana; Notaro, Antonietta; Nguyen, Tam Hong; Sun, Yifan; Guo, Christine C; Lupton, Michelle K; Roberts, Tara L; Lim, Yi Chieh; Oikari, Lotta E; La Bella, Vincenzo; White, Anthony R
Journal of Neuroinflammation - 1/01/2022
Chemoprevention of cutaneous squamous cell carcinoma and its precursors in solid organ transplant recipients using topical sirolimus: a randomized, double-blind, placebo-controlled pilot trial.
Chong, Sharene; Wong, Ho Yi; Althabteh, Ahmad; Cox, Charlotte; Stevenson, Paul; Brown, Susan; Griffin, Anthony; Isbel, Nicole; Siller, Gregory; Soyer, H Peter; Schaider, Helmut; Roy, Edwige; Campbell, Scott; Green, Adele C; Khosrotehrani, Kiarash
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY - 1/01/2022
Clinical Outcomes in Pre-Hospital Activation and Direct Cardiac Catheterisation Laboratory Transfer of STEMI for Primary PCI.
Savage, Michael L; Hay, Karen; Murdoch, Dale J; Doan, Tan; Bosley, Emma; Walters, Darren L; Denman, Russell; Ranasinghe, Isuru; Raffel, Owen Christopher
Heart, lung & circulation - 1/01/2022
Corrigendum to Ng MS, Malacova E, Hurst C, David MC, Johnson DW, Mallett AJ. "Clinical Outcomes of People With Fabry Disease - ANZDATA Registry Study." Kidney Int Rep. 2021;6:2481-2485.
Ng, Monica S; Malacova, Eva; Hurst, Cameron; David, Michael C; Johnson, David W; Mallett, Andrew J
KIDNEY INTERNATIONAL REPORTS - 1/01/2022
Claudin-5 binder enhances focused ultrasound-mediated opening in an in vitro blood-brain barrier model.
Chen, Liyu; Sutharsan, Ratneswary; Lee, Jonathan Lf; Cruz, Esteban; Asnicar, Blaise; Palliyaguru, Tishila; Wasielewska, Joanna M; Gaudin, Arnaud; Song, Jae; Leinenga, Gerhard; Götz, Jürgen
THERANOSTICS - 1/01/2022
Characterising activity and diet compositions for dementia prevention: protocol for the ACTIVate prospective longitudinal cohort study
Smith, Ashleigh E.; Wade, Alexandra T.; Olds, Timothy; Dumuid, Dorothea; Breakspear, Michael J.; Laver, Kate; Goldsworthy, Mitchell R.; Ridding, Michael C.; Fabiani, Monica; Dorrian, Jillian; Hunter, Montana; Paton, Bryan; Abdolhoseini, Mahmoud; Aziz, Fayeem; Mellow, Maddison L.; Collins, Clare; Murphy, Karen J.; Gratton, Gabriele; Keage, Hannah; Smith, Ross T.; Karayanidis, Frini
BMJ Open - 1/01/2022
C5b-9 Membrane Attack Complex Formation and Extracellular Vesicle Shedding in Barrett's Esophagus and Esophageal Adenocarcinoma.
Kolka, Cathryn M; Webster, Julie; Lepletier, Ailin; Winterford, Clay; Brown, Ian; Richards, Renee S; Zelek, Wioleta M; Cao, Yilang; Khamis, Ramlah; Shanmugasundaram, Karthik B; Wuethrich, Alain; Trau, Matt; Brosda, Sandra; Barbour, Andrew; Shah, Alok K; Eslick, Guy D; Clemons, Nicholas J; Morgan, B Paul; Hill, Michelle M
Frontiers in Immunology - 1/01/2022
Response to Lehrer and Rheinstein.
Tuesley, Karen M; Webb, Penelope M; Protani, Melinda M; Spilsbury, Katrina; Pearson, Sallie-Anne; Coory, Michael D; Donovan, Peter; Steer, Christopher; Stewart, Louise M; Pandeya, Nirmala; Jordan, Susan J
JOURNAL OF THE NATIONAL CANCER INSTITUTE - 1/01/2022