A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization.
Ong, Jue-Sheng; Dixon-Suen, Suzanne C; Han, Xikun; An, Jiyuan; , ; , ; Liyanage, Upekha; Dusingize, Jean-Cluade; Schumacher, Johannes; Gockel, Ines; Böhmer, Anne; Jankowski, Janusz; Palles, Claire; O'Mara, Tracy; Spurdle, Amanda; Law, Matthew H; Iles, Mark M; Pharoah, Paul; Berchuck, Andrew; Zheng, Wei; Thrift, Aaron P; Olsen, Catherine; Neale, Rachel E; Gharahkhani, Puya; Webb, Penelope M; MacGregor, Stuart
Nature Communications - 1/01/2021
A multi-ethnic genome-wide association study implicates collagen matrix integrity and cell differentiation pathways in keratoconus.
Hardcastle, Alison J; Liskova, Petra; Bykhovskaya, Yelena; McComish, Bennet J; Davidson, Alice E; Inglehearn, Chris F; Li, Xiaohui; Choquet, Hélène; Habeeb, Mahmoud; Lucas, Sionne E M; Sahebjada, Srujana; Pontikos, Nikolas; Lopez, Karla E Rojas; Khawaja, Anthony P; Ali, Manir; Dudakova, Lubica; Skalicka, Pavlina; Van Dooren, Bart T H; Geerards, Annette J M; Haudum, Christoph W; Faro, Valeria Lo; Tenen, Abi; Simcoe, Mark J; Patasova, Karina; Yarrand, Darioush; Yin, Jie; Siddiqui, Salina; Rice, Aine; Farraj, Layal Abi; Chen, Yii-Der Ida; Rahi, Jugnoo S; Krauss, Ronald M; Theusch, Elisabeth; Charlesworth, Jac C; Szczotka-Flynn, Loretta; Toomes, Carmel; Meester-Smoor, Magda A; Richardson, Andrea J; Mitchell, Paul A; Taylor, Kent D; Melles, Ronald B; Aldave, Anthony J; Mills, Richard A; Cao, Ke; Chan, Elsie; Daniell, Mark D; Wang, Jie Jin; Rotter, Jerome I; Hewitt, Alex W; MacGregor, Stuart; Klaver, Caroline C W; Ramdas, Wishal D; Craig, Jamie E; Iyengar, Sudha K; O'Brart, David; Jorgenson, Eric; Baird, Paul N; Rabinowitz, Yaron S; Burdon, Kathryn P; Hammond, Chris J; Tuft, Stephen J; Hysi, Pirro G
Communications Biology - 1/01/2021
Polygenic Risk Scores Stratify Keratinocyte Cancer Risk among Solid Organ Transplant Recipients with Chronic Immunosuppression in a High Ultraviolet Radiation Environment.
Seviiri, Mathias; Law, Matthew H; Ong, Jue Sheng; Gharahkhani, Puya; Nyholt, Dale R; Hopkins, Peter; Chambers, Daniel; Campbell, Scott; Isbel, Nicole M; Soyer, H Peter; Olsen, Catherine M; Ellis, Jonathan J; Whiteman, David C; Green, Adele C; MacGregor, Stuart
Journal of Investigative Dermatology - 1/01/2021
Automated AI labeling of optic nerve head enables insights into cross-ancestry glaucoma risk and genetic discovery in >280,000 images from UKB and CLSA.
Han, Xikun; Steven, Kaiah; Qassim, Ayub; Marshall, Henry N; Bean, Cameron; Tremeer, Michael; An, Jiyuan; Siggs, Owen M; Gharahkhani, Puya; Craig, Jamie E; Hewitt, Alex W; Trzaskowski, Maciej; MacGregor, Stuart
AMERICAN JOURNAL OF HUMAN GENETICS - 1/01/2021
Association of Monogenic and Polygenic Risk With the Prevalence of Open-Angle Glaucoma.
Siggs, Owen M; Han, Xikun; Qassim, Ayub; Souzeau, Emmanuelle; Kuruvilla, Shilpa; Marshall, Henry N; Mullany, Sean; Mackey, David A; Hewitt, Alex W; Gharahkhani, Puya; MacGregor, Stuart; Craig, Jamie E
JAMA ophthalmology - 1/01/2021